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The formation of ALCAR originates with cytoplasmic thiokinase which forms acyl-Coenzyme A from free fatty acids, ATP and Coenzyme A (CoA) [12]

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For instance, melittin-LPNs have been reported with a core of melittin/aspartate, a lipid membrane as the middle layer, and PEG as the outer shell, which can significantly improve the delivery efficiency of melittin in the body and inhibit the proliferation of tumour cells 41

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