doi: 10.1158/1078-0432.CCR-14-1200
Epileptogenesis is defined as the latent period between the initial brain insult and the first unprovoked seizure, where very intensive neuronal alterations take place, including oxidative stress, the expression of pro-inflammatory mediators, neurodegeneration, reactive gliosis, damage to the blood-brain barrier, increased epileptiform spiking, and spontaneous recurrent seizures (Borowicz-Reutt and Czuczwar 2020)
IFN-gamma producing Th1 cells induce different transcriptional profiles in microglia and astrocytes
More than 50% of patients discontinue GLP-1 therapy within 12 months Real-world dosing often falls below therapeutic levels, compromising results Emerging drugs like VK2735 and amycretin show promise for better outcomes Integrated tech-enabled care improves adherence and weight loss Mental health impacts are both hopeful and concerningand need attention Table of Contents GLP-1 Trends vs
MTHFR gene mutations can lead to nutritional deficiencies, fatigue, mental health issues, cardiovascular problems, and even neural problems in growing fetuses
