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Importantly, we found that phosphorylation of serine 727 residue of STAT3, p-STAT3-S727, increased in hyperaminoacidemia-treated cells, further elevating Vgf transcription in an mTOR-dependent manner

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A common clinical observation has been that, as the child gains core strength and increased sensation in the oral-motor pathways, oral stims sometimes become more frequent (and alarm the parent that the child is regressing)