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Interestingly, there is a remarkable absence of cAMP-responsive elements (CRE) and Ca 2+ responsive elements (CaRE) in the promoter region of POMC despite the demonstrated importance of cAMP and Ca 2+ in the intracellular signaling of corticotrophs and melanotrophs

Putative pro-cognitive molecules shift the pattern of both low and high frequency waveforms toward normal patterns indicating improvements in synaptic function

Nutritional Deficiencies A lack of essential vitamins such as vitamin B12 and folic acid can lead to a low platelet count

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