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Furthermore, intestinal I/R injury can activate the vagus nerve, transmitting signals to the brain that influence neuronal activity and cognitive function, and alter gut microbial metabolite production, such as short-chain fatty acids (SCFAs), thus affecting neuronal signaling and cognitive processes (Wu et al., 2021

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The study found that caffeine protected against MeHg-induced toxicity via glutamate transmission, but this protective effect was only partially reversed when caffeine was co-stimulated with glutamine and IFN- [140]