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It is considered conditionally essential, with supplementation becoming relevant only in specific circumstances

For example, in the STEP UP Diabetes trial, participants taking 7.2 mg of semaglutide weekly lost an average of 13.2% of their initial weight, compared to 10.4% for those on the standard 2.4 mg weekly dose

Time-intensive with multiple clinic visits

In one observational study of 69 people with obesity, the proportion reporting emotional eating dropped from 72.5% to 11.5% after three months of semaglutide ( Nicolau et al., Physiology & Behavior, 2022 )

Injection Site Reactions: The most common adverse reactions are typically localized to the administration site