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12 Together, these events converge to trigger the death of dopaminergic neurons and elicit PD (Figure 1)

Any cloudiness, discoloration, or persistent particles indicates degradation requiring disposal

Random splicing of several exons caused by a single base change in the target exon of CRISPR/Cas9-mediated gene knockout

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Summary Keywords GSH synthesis inhibition, BSO, brain protection, xCT, Nrf2 Citation Valdovinos-Flores C, Limn-Pacheco JH, Len-Rodrguez R, Petrosyan P, Garza-Lomb C and Gonsebatt ME (2019) Systemic L-Buthionine -S-R-Sulfoximine Treatment Increases Plasma NGF and Upregulates L-cys/L-cys2 Transporter and -Glutamylcysteine Ligase mRNAs Through the NGF/TrkA/Akt/Nrf2 Pathway in the Striatum