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Because Health Canada has not yet approved e-cigarettes as delivery vehicles for nicotine, they are illegal to sell in Canada.Reference Czoli, Reid and Rynard 2 Regardless, both nicotine and non-nicotine containing e-cigarette products are widely available for purchase in Canada

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These increased inflammatory factors and chemokines leads to further infiltration of immune cells into the respiratory tract, resulting in dysfunctions of fibroblasts, goblet cells, and epithelial cells, ultimately leading to emphysema, mucus accumulation, inflammation, and pulmonary fibrosis [52]

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