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The peptide is generally well-tolerated, with few reported side effects

Their phase 3 study (Curr Neuropharmacol, 2016) demonstrated that injectable BPC-157 at 10 mcg/kg body weight accelerated healing in various tissue types, including gastric ulcers, tendon injuries, and bone fractures in animal models

Without adequate collagen production and proper organization of collagen fibers, wounds heal with reduced strength and may be more prone to reopening or developing problematic scars

GRK2 prevents the shift of M1 into M2 macrophages by mediating PGE2-EP4-cAMP-CREB signaling in synovial macrophages (136)

Hollands C et al (2017) Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimers disease by compromising hippocampal inhibition