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HDAC6 regulates various cellular processes, including cell motility, cell migration, endocytosis, aggresome formation and autophagy etc., by deacetylating cytoplasmic proteins, such as cortactin, heat shock protein 90 (HSP90) and -tubulin [34]

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The increase in cAMP activates downstream signaling cascades, primarily through protein kinase A (PKA), and upregulates the expression of melanogenic enzymes, resulting in increased eumelanin synthesis and visible skin darkening (Figure 4)

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