CAFs also activate Pyruvate kinase M2 (PKM2) in PC cells
doi: 10.1016/j.neurobiolaging.2020.01.004 123 LiuH.DearA
Past-date creatine is generally safe, just potentially less potent
Other drugs more frequently associated with osteomalacia include aluminum containing antacids, bisphosphonates, cholestyramine, isoniazid, phenytoin, phenobarbital, rifampicin, saccharated ferric (iron) oxide, and metals like aluminum, cadmium, and lead
For endurance athletes specifically, Centner, Jerger, and Knig published a randomized controlled trial in Nutrients (2023) examining recreationally active men who combined 12 weeks of concurrent training60 minutes of moderate-intensity running plus 15 minutes of dynamic resistance workwith daily SCP supplementation