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Downstream processing includes broth pasteurization, isolation, purification, recrystallization, and drying of riboflavin ( The annual total riboflavin market is approximately 9000 t, and the final price is approximately $15/kg for the feed-grade product and $3550/kg for the food-grade product ( Commercial riboflavin production is currently based on industrial fermentation using overproducing strains of genetically engineered microorganisms

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Wagner JG, Jiang Q, Harkema JR, Ames BN, Illek B, Roubey RA, Peden DB: Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma

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