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Finally, because selection might take place at other X-linked loci, heterozygotes exhibiting extreme phenotypes by analysis of G6PD may arise from selection acting on an allele at another locus (a hitchhiking effect), as has been suggested in a family with G6PD Ilesha

In normal physiology it participates in hepatic fat processing and methylation reactions, and it contributes to the livers handling of triglycerides and cholesterol