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When a person with Down syndrome has vitamin B12 and/or folate deficiency, the increase in the homocysteine level may not be great enough to overcome this starting low value of homocysteine
For compounds identified at or above the Analytical Evaluation Threshold (AET), safety assessment is required per ICH Q3E
Linda Bluestein: Okay, great
Patients should be aware of the risk of diabetic retinopathy complications , particularly with semaglutide, especially in those with pre-existing retinopathy and rapid improvements in blood glucose
In extreme cases, dialysis may be required to remove excess potassium
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