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Bromocriptine administration reduces hyperphagia and adiposity and differentially affects Dopamine D2 receptor and transporter binding in leptin-receptor-deficient zucker rats and rats with diet-induced obesity

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The finding that the prandial state does not have a clinically significant effect on the PK of orforglipron offers dosing convenience to patients by removing the requirement of a fed or a fasted state and is anticipated to be a significant advantage for treatment adherence and thus therapeutic effectiveness

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