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[21] 6-Phosphoglucono--lactone + H 2 O 6-Phosphogluconate Oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate In the final step of the oxidative phase, 6-phosphogluconate undergoes an oxidative decarboxylation , producing: ribulose 5-phosphate, a keto-pentose

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This inhibitory effect promoted the accumulation of Fe 2+ in the cells, depleted reduced GSH, and suppressed the expression of xCT and GPX4, ultimately triggering iron ferroptosis