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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Demirta H, zer A, Yldrm AK, Dursun AD, Sezen C, Arslan M

Scientific discussion surrounding IGF-1 LR3 often highlights its interaction with IGF-1 receptors and its role within cellular signaling models involving regulated communication processes such as proliferation, differentiation, and metabolic pathway signaling

That leaves Osborn without a significant role

Given recent advances in our understanding of metformin transport in the gut, the incretin system, the potential gutbrain axis and the complexities of the microbiome, more research in these areas would doubtless further improve our knowledge and understanding of metformin action and tolerance

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