Weight reduction that is substantial (14%) and rapid (over 3-4 mo) is associated with significant bone loss, 71 whereas more moderate and slower weight reduction may better preserve bone mass
Devices with lower power needs work fine with lower C ratings

[5] [2] Patients starting GLP-1 therapy should be aware of: Potential mood changes during the adjustment period, particularly if experiencing significant gastrointestinal side effects The importance of continuing existing mental health treatments unless advised otherwise by their healthcare team Realistic expectations regarding weight loss and metabolic improvements, as unrealistic goals can lead to disappointment Healthcare professionals prescribing GLP-1 agonists should: Screen for depression and anxiety at baseline and during follow-up appointments Monitor for mood changes , particularly in patients with pre-existing mental health conditions Ensure coordinated care between diabetes/obesity services and mental health teams when appropriate It is essential to recognise that GLP-1 agonists are not a substitute for evidence-based depression treatments, including psychological therapies and antidepressant medications when indicated
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Despite still being in the testing phase and not FDA approved or legal to sell, many Americans are willing to shell out big bucks to get their hands on the next generation of GLP-1 from Eli Lilly