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GLP-1 medications are unsuitable for individuals with: A personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia type 2 (MEN 2) They should also be used with caution in patients with severe gastrointestinal disease

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If weight increases or remains unchanged for 3-4 consecutive weeks, the protocol is not working regardless of how you feel

doi: 10.1016/s0304-3835(01)00797-2 72 XinHDengYCaoJ

Another study also found that acylcarnitine C3:0 was decreased in the end-stage renal disease (ESRD) with depression than those without depression and C3:0 had a good ability to diagnose depression in the ESRD (AUC = 0.934) (42)