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Gasbjerg LS, Hartmann B, Christensen MB, et al

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The reason for occurring this phenomenon (reduction of CySGly- but not of GS-bound Mercury(II)) in solution and in the biological environment of cells is reasonably a consequence of the low reducing electrochemical potential of CySGly (at 0.282 V the most reducing one of the whole soluble physiological thiolome)

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295 Excessive mutHTT can overwhelm the UPS, dysregulating proteostasis and further promoting mutHTT accumulation