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While theyre fundamentally similar medications, they differ slightly in their mechanism of action: Wegovy (semaglutide) is a GLP-1 agonist Zepbound (tirzepatide) is a dual agonist: GLP-1 + a glucose-dependent insulinotropic polypeptide (GIP) Both semaglutide and tirzepatide affect the hypothalamus and the hedonic eating centers, the brains center of appetite and cravings

In addition, a 2024 study found that people taking another GLP-1 drug, liraglutide, had a 179% higher risk of developing NAION

If you are interested in participating in a clinical trial involving retatrutide, the NIHR Be Part of Research portal (bepartofresearch.nihr.ac.uk) is the authoritative UK resource for finding relevant research studies

These findings also have important implications for evolving guidelines

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