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Note: see Appendix for an abbreviated summary of strikingly limited head-to-head RCT evidence that exist at the time of this writing Matiegka defines FFM as bone + skeletal muscle + connective tissue + organs + water

This chronic immune stimulation contributes to systemic inflammation, immune exhaustion, and the ebbing-and-flowing symptom pattern many long COVID patients describe, where they feel marginally better and then crash again

Freeman AM, Pennings N

Target levels above 30 ng/mL, ideally between 40-60 ng/mL

Immunomodulatory Effect of Withania somnifera (Ashwagandha) ExtractA Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants