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SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks

Still, the MHRA makes these determinations on a case-by-case basis when complaints are received or manufacturers seek advice

10.1016/s0021-9258(18)53392-5 29 EsserV.BrownN

These additional excretion pathways collectively contribute to maintain TMAO balance in the body (Gessner et al., 2020)

What works well for one individual may not be as effective for another