2026 (Clinical Obesity) Narrative review, 6 studies, 480,825 adults
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Stress and its impact on the digestive system are also increasingly being recognized as contributors to the onset and exacerbation of diverticulitis
Residents near Parris Island and across Port Royal Island deserve access to specialized care
Summary of REDEFINE 1 and REDEFINE 2 trials with CagriSema, presented this week at #ADA2025 and published in NEJM: REDEFINE 1: 3,417 participants with obesity or overweight (without diabetes) treated with CagriSema achieved a 22.7% weight loss after 68 weeks, compared to 2.3% with placebo 40.4% of participants on CagriSema achieved a weight loss of 25% or more The weight loss was slightly below the company's initial expectations of at least 25% REDEFINE 2: 1,206 participants with obesity or overweight and type 2 diabetes treated with CagriSema achieved a 15.7% weight loss after 68 weeks, best in the category thus far , compared to 3.1% with placebo 89.7% of participants achieved a weight loss of 5% or more Mean HbA1c reduction of 2.07% Article links: nejm.org/doi/full/10.10 nejm.org/doi/full/10.10 Summary of REDEFINE 1 and REDEFINE 2 trials with CagriSema, presented this week at #ADA2025 and published in NEJM: REDEFINE 1: 3,417 participants with obesity or overweight (without diabetes) treated with CagriSema achieved a 22.7% weight loss after 68 weeks, compared to 2.3% with placebo 40.4% of participants on CagriSema achieved a weight loss of 25% or more The weight loss was slightly below the company's initial expectations of at least 25% REDEFINE 2: 1,206 participants with obesity or overweight and type 2 diabetes treated with CagriSema achieved a 15.7% weight loss after 68 weeks, best in the category thus far , compared to 3.1% with placebo 89.7% of participants achieved a weight loss of 5% or more Mean HbA1c reduction of 2.07% Article links: nejm.org/doi/full/10.10 nejm.org/doi/full/10.10 Hopefully primary prevention in normal weight is next Pharma has obesity in its sights
