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also reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Bristol Myers Squibb (presentation on GBD 2021 findings for anemia and dietary iron deficiency), outside the submitted work

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Furthermore, cigarette smoke can activate the autophagy-dependent mechanism mediated by the deacetylase HDAC6, while causes the cilia proteins to be delivered to the lysosome for degradation or recycling, shortening the airway cilia ( in vitro to cause e-cadherin-mediated barrier function destruction of airway epithelial cells, leading to increased infection risk by viruses and bacteria that exacerbate COPD (Oldenburger et al., 2014)

6 Nurses can and often do step into the role for counseling, but many nurses may not have time or expertise in smoking cessation counseling