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Topical and oral preparations can be used to maintain, but they are not able to achieve the same systemic dose concentration as IV delivery

Toxins 11:466

Hazel leaf polyphenol extract alleviated cisplatin-induced acute kidney injury by reducing ferroptosis through inhibiting Hippo signaling

If your body can only use 10% of what you swallow, the remaining 90% has to go somewhereusually sitting in your gut where it can cause the very side effects we are discussing