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Petricca et al., 2023), and a positive correlation between IL-1 levels and COX-2 expression has been described in the testes of infertile patients (Matzkin et al., 2010

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We further confirmed this by immunohistochemistry, showing that LPS-treated placentas have more pH2A.X-positive cells in the labyrinth exchange region and the maternal decidua, whereas NR intervention normalized this effect to control levels (Fig 4M and N)