Central nervous system effects include actions on hypothalamic appetite centers, contributing to reduced caloric intake and subsequent weight loss
GLP-1 receptor agonists have been used successfully and safely in type 2 diabetes mellitus (T2DM) and do not induce insulin desensitization after prolonged use, as they do not activate insulin receptors in normoglycemic subjects [16] and thus do not cause hypoglycemia
Harbour SN, Maynard CL, Zindl CL, Schoeb TR, Weaver CT
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