When people with serious conditions like cancer pursue coffee enemas instead of or alongside proven therapies, they may delay effective treatment during critical windows
On one hand, a large 2024 cohort study (over 160,000 patients with obesity) reported a significantly higher incidence of new psychiatric diagnoses among GLP-1 RA users: an ~98% increase in risk of any psychiatric disorder compared to matched non-users, including a 195% higher risk of major depression and ~106% higher risk of suicidal behavior (Scientific Reports 2024)
Common pathophysiological mechanisms of metabolic syndrome and NDD include insulin resistance of the brain, neuroinflammation, oxidative stress, dysfunction of the BBB, mitochondrial damage, dysbiosis of the intestinal microbiota and changes in the renin-angiotensin system
That is the pattern
In addition, in subjects with ESRD, the area under the SNAC plasma concentrationtime curve from time zero to 4 h (AUC 4 ) after dosing was calculated during haemodialysis on day 9 and with no haemodialysis on day 10 and these were compared using a linear normal model with log-transformed endpoint as dependent variable and haemodialysis (yes/no) and subject as fixed factors
