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However, in order to reach the systemic circulation and exert any salubrious functions, a food component must maintain its molecular structure through several phases of digestion that each present a significant metabolic challenge for the molecule and affect its eventual rate and extent of absorption [33,34]

doi: 10.1128/IAI.00955-19 73 DerkaouiM.AntunesA.Nait AbdallahJ.PoncetS.MazA.Ma PhamQ

Freezing reconstituted peptide solutions can cause ice crystals to form that damage the protein structure