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GLP-1 GLP-1 , 2 (T2DM) .213,214,215 GLP-1 T2DM GLP-1 - - T2DM .132,216,217 GLP-1 .3 - .130,218 GLP-1 (GLP-1R) cAMP (CREB) .3,130,219 GLP-1 cAMP PKA EPAC .1,220 PKA , , .178,180 PI3K/GLP-1 Akt - .221,222 Akt Forkhead box O1 (FoxO1) 2 (GLUT2) - .223,224 GLP-1 - , .131,225 GLP-1 - .131 GLP-1 , .131,226 GLP-1 - cAMP .227 - cAMP .228 cAMP PKA - K-ATP .228,229 ATP/ADP .229 , PKA K-ATP .230,231 K-ATP GLP-1 - .232,233 GLP-1 -
The marketing environment after April 22 is the most likely near-term enforcement zone
The 90% confidence intervals (CIs) for the AUC and C max of warfarin in most studies were generally contained within the pre-specified 0.81.25 limits that are used to assess significance of drug-drug interactions
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