Other Oral GLP-1 Options: Liraglutide (Saxenda): Injectable only (not oral) Daily injections required Older GLP-1 medication Less effective than semaglutide or tirzepatide Not available in oral form Dulaglutide (Trulicity): Injectable only (not oral) Once-weekly injection Primarily for diabetes Not available in oral form Exenatide (Byetta, Bydureon): Injectable only (not oral) Twice daily or once weekly depending on formulation Older GLP-1 medication Not available in oral form Bottom Line on Current Options: If you want an oral GLP-1 medication right now, Rybelsus is your only option, but its significantly less effective for weight loss than injections
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Conversely, in HF with reduced ejection fraction (HFrEF), especially in advanced stages, caution is necessary due to potential increases in heart rate and arrhythmic events [71]
Michigan Medicine: University of Michigan
