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The mitochondrial energy pathway MOTS-c targets responds differently depending on the patients metabolic baseline, and we want to confirm the conditions where you will see meaningful results

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p53 is nicknamed the guardian of the genome because it is a tumor supressor when it detects mutation in the cells DNA (which can turn the cell into cancer), it causes apoptosis (in fact, lots of cancers are associated with genetic mutations that switch off p53, meaning that p53 stops working and cant kill the cell before it forms a tumor and possibly becomes cancerous)

For instance, estrogen may interfere with the cross-linking process, leading to a reduction in the mechanical integrity of collagen fibrils