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Nmeth I, Boda D

Unlike peptide-based incretins, this is a Small Molecule Inhibitor targeting the cytosolic enzyme Nicotinamide N-methyltransferase (NNMT)

Women who received concurrent menopause hormone therapy lost 35% more total body weight than those on tirzepatide alone 17% versus 14% at 15 months along with improved cardiometabolic outcomes

Antioxidant prevent the oxidative damage and counter the deleterious effects on human health through cellular mechanisms by either catalytic removal or binding with free radicals, or electron donation processes [75]

Therefore, it seems highly plausible that oxidative stress in the brain compromises bio-chemical integrity of the hippocampus and the amygdala