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The complete selection process, including the number of records identified, screened, and excluded with explicit reasons (separated for preclinical and clinical/epidemiological literature), is documented in the PRISMA flow diagram (Figure 1)

While there is no official FDA-mandated water intake specifically for GLP-1 medications, clinical experience and general hydration guidelines provide a practical framework for patients

However, while psyllium husk has the potential to remedy stomach issues, it can also worsen them

Januvia requires dose adjustment when eGFR falls below 45 mL/min/1.73m, with a reduced dose of 50mg daily for moderate impairment (eGFR 30-45) and 25mg daily for severe impairment (eGFR below 30)

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