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Lifestyle counseling and management of coexisting diseases were recommended in alignment with guidelines

PMID 15345657

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A landmark 2025 analysis of the SEER 17 database found a dramatic improvement in amelanotic melanoma survival outcomes driven entirely by the introduction of modern immunotherapy: 2-year distant-stage survival (20002005): 26.4% 2-year distant-stage survival (20162021): 58.8% That represents more than a doubling of survival for Stage IV patients

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