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On the contrary, microsomal GSTs, also known as MAPEG (membrane-associated proteins involved in eicosanoid and glutathione metabolism), are integral membrane proteins which are not evolutionary related to the other major classes

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Brain Res Brain Res Rev 20:269287 Gilgun-Sherki Y, Rosenbaum Z, Melamed E, Offen D (2002) Antioxidant therapy in acute central nervous system injury: current state

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It is very likely that the effect of A1AT is not direct on lymphocytes, but it is mediated by the alteration in the extracellular milieu (i.e