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These context-dependent effects of cellular processes, transcription factors, and metabolites are present in many aspects of biology, influenced by the concomitant expression of receptors, metabolic enzymes/pathways of each cell, molecular partners, and convergent or divergent signaling/ transcription factors activation
Gardner J
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Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds
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