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The metabolite HYA partially restores the integrity of the intestinal epithelial barrier via the GPR40-MEK-ERK pathway, as reported in human Caco-2 cells and the murine DSS-colitis model (126)

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However, clinical markers for -cell function can be confounded by glucose toxicity, and appropriate markers for the residual -cell function remain elusive

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To date, the modulation of proteins and enzymes against oxidative stress and inflammation is known as its main action, by means of activating the transcription of antioxidant response elements (ARE)

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