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Rats with fasting blood glucose concentrations 11.1 mmol/L for three continuous days were considered as successful diabetes models (Srinivasan et al., 2005)

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In the United States, Candida albicans causes about 60,000 cases of systemic infections each year, and the damage amounts to 2 to 4 billion dollars [5, 6]

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A role of oxidative stress in GO is supported by a number of basic studies suggesting that ROS promote the proliferation of OFs and the release of GAGs, the synthesis and secretion of cytokines, and the expression of other factors involved in the pathogenesis of GO, namely heat shock protein 72 (HSP-72), HLA-DR and ICAM-1 ( Figure 1 In this context, a number of studies, performed both in vitro and in vivo , investigated the effects of antioxidant agents in GO, including selenium, pentoxifylline, quercetin, enalapril, vitamin C, N-acetyl-L-cysteine and melatonin ( Oxidative Stress and Proliferation of Orbital Fibroblasts Burch et al