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Black or tarry stool, visible blood in the stool, vomiting blood, severe abdominal pain, unexplained weight loss, persistent fever, anemia, or progressive swallowing difficulty should be evaluated appropriately

In exploratory analysis of the WILLOW study, brensocatib treatment significantly reduced serum NE activity and sputum-related NSP activity, demonstrating broad anti-inflammatory effects ( Basic research further reveals multiple anti-inflammatory mechanisms of DPP1 inhibition: reduced NET formation, thereby decreasing NET-mediated tissue damage

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