XFZYD can significantly improve spatial memory in rats with traumatic brain injury and reduce the modified neurologic severity score and arachidonic acid, TNF-, and IL-1 levels
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Thus, dysbiosis initiates immune imbalance through a two-hit mechanism: the loss of tolerogenic metabolites and the active stimulation of innate immunity by pathobionts, establishing the systemic inflammatory cascade that culminates in neuroinflammation ( Of particular relevance to this review, the gut microbiota is an indispensable modulator of the hosts immune system ( Communication between the gut and the brain is bidirectional and occurs through multiple interconnected pathways, which constitute the MGBA
