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Yet another small molecule that has been studied extensively as a highly potent small molecule inhibitor of both human and murine CD38 is 78c, which has been shown to be 10-fold less potent against the cyclase activity than the hydrolase activity of recombinant human CD38 139

It is administered via a weekly subcutaneous injection using a pen

Nutrient Deficiencies Risk When Combining GLP-1 Therapy and PPIs The combination of omeprazole and GLP-1 receptor agonists creates a compounding effect on nutrient absorption that requires monitoring

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Berruyer C, Martin FM, Castellano R, Macone A, Malergue F, et al