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Experiments showed that the GlcNAc-reactive B cell response to group A streptococci appeared to delay Type 1 diabetes, potentially by facilitating efficient clearance of apoptotic beta cells, thereby limiting activation of killer and helper T cells that ultimately would destroy healthy beta cells

The apical surfaces of these cells have brush borders that consist of numerous long regularly oriented, and closely packed thin finger-like projections, microvilli, which project into a narrow tubular lumen

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10.1016/s0896-6273(00)00128-8 224 YasudaK.ItakuraM.AoyagiK.SugayaT.NagataE.IharaH.et al (2011)

The estrogen-deficient state may disrupt this careful coordination of energy substrate uptake and utilization, impairing postprandial insulin-mediated suppression of adipose tissue lipolysis and leading to a chronic excess supply of circulating NEFA to the liver, eventually overwhelming its capacity for lipid removal to cause liver fat accumulation (86)