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Overall, most of those papers are in favor of a possible contribution of polymorphisms in folate-related genes as maternal risk factors for the birth of a child with DS, however, they are often conflicting and limited by the small sample size of case-control cohorts (Table 1)

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Most side effects are dose-dependent, especially nausea and gastrointestinal disturbances

Biochem J 449:479489

The genetic landscape of T1D is complex, dominated by HLA and INS loci that govern immune tolerance, but also involving non-HLA genes that modulate the hosts response to environmental factors like viruses and the gut microbiome