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Appendix 1

While, previously, patients with severe OSA would likely require CPAP therapy for the remainder of their lives, especially as OSA tends to worsen with age and weight increase, these obesity-targeting medications offer the potential for some patients to become less dependent on CPAP or be managed using lower, more tolerable pressures. Indeed, patients on tirzepatide had about a 50% reduction in the apnea-hypopnea index and significant improvements in hypoxemia

It is a key regulatory enzyme and signaling factor for two major incretin hormones: Glucagon-like peptide-1/2 (GLP-1/2) and glucose-dependent insulinotropic polypeptide (GIP) (37, 38)

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Small variations in timing occasionally occur for many people