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This triple-agonist mechanism makes it a subject of intense interest in metabolic research, exploring pathways related to energy expenditure, glucose control, and appetite regulation

Although preclinical studies and limited clinical trials provide supportive evidence, larger and well-designed human clinical trials are still required to confirm long-term efficacy, dose-response relationships, and safety in metabolic disease conditions

Cao S, Yan B, Lu Y, Zhang G, Li J, Zhai W, Guo W, Zhang S

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NTZ replicated findings similar to those of the ER stress inhibitor (4-PBA) used in the study, further supporting our conclusion