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Single-particle structure determination has been carried out with Relion v3.1.2 88 after motion-correction using 5 5 patches 89 and CTF estimation 90

Moreover, homocysteine can cross the blood-brain barrier, directly triggering neuroinflammation and the profound cognitive impairmentoften described as "brain fog"that ranks among the most debilitating symptoms of Long COVID

Mitochondria isolation and ELISA Mitochondria was isolated from primary OL cultures using Mitochondria Isolation Kit for Cultured Cells (#89874) (Thermo Fisher Scientific, Waltham, MA) as per the manufacturers exact instructions

High TMAO concentration is associated with long-term mortality in patients with CKD and coronary atherosclerosis (Stubbs et al., 2016

Here, we established that LCAD-KO mice also exhibit multiple signs of muscle dysfunction, such as significantly reduced basal locomotion, reduced grip strength, and reduced latency to fall on the hanging wire test (Supplemental Figure 1