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Difficulties arising from potential immunogenicity, large molecular weight, need for carriers for their delivery and instability in vivo are well recognized [188]

B12, available in forms like Cyanocobalamin or Methylcobalamin, is essential for DNA synthesis, energy creation, and the breakdown of fats and proteins

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NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme at the center of mitochondrial energy production, sirtuin (longevity-enzyme) activity and DNA repair and its levels decline with age