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Diabetes 59:479485 Schfer SA, Mssig K, Staiger H et al (2009) A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion

It's a vascularized connective tissue matrix with lymphatic drainage that governs peptide absorption kinetics in ways muscle tissue cannot replicate

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However, with very limited quantity and quality of the related evidences, we believe trials investigating self-administered coffee enema are needed to draw more concrete conclusions on either in terms of effectiveness or safety with plausible mechanism

Its cognition-enhancing effects may be due to an ability to influence the brains levels of noradrenaline, serotonin, and dopamine,4 three neurotransmitters with well-documented relationships to vigilance, attention, learning,5 memory,6 and the motivation toward cognitive effort.7 Meanwhile, its anxiolytic effects appear to be GABAergic (i.e., relating to the neurotransmitter GABA)